I have a time-to-event variable, where the occurrence of event is determined by 5 numerical components measured at pre-specified timepoints. Missing values are observed for some components at some timepoints. My question is, is it feasible to apply multiple imputation on the component scores in this instance?
For each imputation, a different choice of imputed values may also change whether an event has occurred for each subject, resulting in different event/censor distributions. Considering this, would Rubin's Rule still apply here to combine the KM/HR estimates for an overall result?