How to enable Windows console QuickEdit Mode from python?

You can use ctypes to call GetConsoleMode and SetConsoleMode.

ctypes definitions:

import msvcrt
import atexit
import ctypes
from ctypes import wintypes

kernel32 = ctypes.WinDLL('kernel32', use_last_error=True)

# input flags
ENABLE_PROCESSED_INPUT = 0x0001
ENABLE_LINE_INPUT      = 0x0002
ENABLE_ECHO_INPUT      = 0x0004
ENABLE_WINDOW_INPUT    = 0x0008
ENABLE_MOUSE_INPUT     = 0x0010
ENABLE_INSERT_MODE     = 0x0020
ENABLE_QUICK_EDIT_MODE = 0x0040
ENABLE_EXTENDED_FLAGS  = 0x0080

# output flags
ENABLE_PROCESSED_OUTPUT   = 0x0001
ENABLE_WRAP_AT_EOL_OUTPUT = 0x0002
ENABLE_VIRTUAL_TERMINAL_PROCESSING = 0x0004 # VT100 (Win 10)

def check_zero(result, func, args):    
    if not result:
        err = ctypes.get_last_error()
        if err:
            raise ctypes.WinError(err)
    return args

if not hasattr(wintypes, 'LPDWORD'): # PY2
    wintypes.LPDWORD = ctypes.POINTER(wintypes.DWORD)

kernel32.GetConsoleMode.errcheck= check_zero
kernel32.GetConsoleMode.argtypes = (
    wintypes.HANDLE,   # _In_  hConsoleHandle
    wintypes.LPDWORD,) # _Out_ lpMode

kernel32.SetConsoleMode.errcheck= check_zero
kernel32.SetConsoleMode.argtypes = (
    wintypes.HANDLE, # _In_  hConsoleHandle
    wintypes.DWORD,) # _Out_ lpMode

The following wraps the underlying WinAPI functions as get_console_mode and set_console_mode. I've limited the wrappers to operating on just the console's active input buffer or active output buffer, i.e. \\.\CONIN$ and \\.\CONOUT$. I think this is simpler than having to worry about file descriptors and handles. Notably sys.stdin and sys.stdout may be redirected elsewhere, as may also be the case for the C runtime's standard I/O FILE streams, file descriptors, and the Windows standard handles that you can get from GetStdHandle. In these cases you can still open CONIN$ and CONOUT$, as long as the process is attached to a console.

def get_console_mode(output=False):
    '''Get the mode of the active console input or output
       buffer. Note that if the process isn't attached to a
       console, this function raises an EBADF IOError.
    '''
    device = r'\\.\CONOUT$' if output else r'\\.\CONIN$'
    with open(device, 'r+') as con:
        mode = wintypes.DWORD()
        hCon = msvcrt.get_osfhandle(con.fileno())
        kernel32.GetConsoleMode(hCon, ctypes.byref(mode))
        return mode.value

def set_console_mode(mode, output=False):
    '''Set the mode of the active console input or output
       buffer. Note that if the process isn't attached to a
       console, this function raises an EBADF IOError.
    '''
    device = r'\\.\CONOUT$' if output else r'\\.\CONIN$'
    with open(device, 'r+') as con:
        hCon = msvcrt.get_osfhandle(con.fileno())
        kernel32.SetConsoleMode(hCon, mode)

update_console_mode combines the latter functions to let you pass in the flags you want to set and the mask of flags to modify. This includes flags to clear. It also allows restoring the previous mode by registering an atexit function.

def update_console_mode(flags, mask, output=False, restore=False):
    '''Update a masked subset of the current mode of the active
       console input or output buffer. Note that if the process
       isn't attached to a console, this function raises an
       EBADF IOError.
    '''
    current_mode = get_console_mode(output)
    if current_mode & mask != flags & mask:
        mode = current_mode & ~mask | flags & mask
        set_console_mode(mode, output)
    else:
        restore = False
    if restore:
        atexit.register(set_console_mode, current_mode, output)

Example:

if __name__ == '__main__':
    import os
    import sys
    import time

    if sys.stderr is None:
        os.close(2)
        sys.stderr = open('stderr.txt', 'w', buffering=1)

    print("%#06x, %#06x" % (get_console_mode(),
                            get_console_mode(output=True)))    

    flags = mask = ENABLE_EXTENDED_FLAGS | ENABLE_QUICK_EDIT_MODE
    update_console_mode(flags, mask, restore=True)

    print("%#06x, %#06x" % (get_console_mode(),
                            get_console_mode(output=True)))    

    time.sleep(10) # check console properties